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Adult soft tissue sarcoma is a disease in which malignant (cancer) cells form in the soft tissues of the body. A sign of adult soft tissue sarcoma is a lump or swelling in soft tissue of the body. Adult soft tissue sarcoma is diagnosed with a biopsy. 

Risk factors for soft tissue sarcoma include the following inherited disorders: 

  • Retinoblastoma.
  • Neurofibromatosis type 1 (von Recklinghausen disease).
  • Tuberous sclerosis (Bourneville disease).
  • Familial adenomatous polyposis (FAP; Gardner syndrome).
  • Li-Fraumeni syndrome.
  • Werner syndrome (adult progeria).
  • Nevoid basal cell carcinoma syndrome (Gorlin syndrome).

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